REST (RE1-silencing transcription factor)

REST ( RE 1 - silencing transcription factor )

Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death.

Resveratrol (3,5,4'-trihydroxystilbene) (RSV), a polyphenol widely present in plants, exerts a neuroprotective function in several neurological conditions; it is an activator of class III histone deacetylase sirtuin1 (SIRT1), a crucial regulator in the pathophysiology of neurodegenerative diseases. By contrast, the RE1-silencing transcription factor (REST) is involved in the neurotoxic effects ...

Regulation of neural gene transcription by optogenetic inhibition of the RE1-silencing transcription factor.

Optogenetics provides new ways to activate gene transcription; however, no attempts have been made as yet to modulate mammalian transcription factors. We report the light-mediated regulation of the repressor element 1 (RE1)-silencing transcription factor (REST), a master regulator of neural genes. To tune REST activity, we selected two protein domains that impair REST-DNA binding or recruitment...

MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression.

A key hub for the orchestration of epigenetic modifications necessary to restrict neuronal gene expression to the nervous system is the RE1 silencing transcription factor (REST; also known as neuron restrictive silencer factor, NRSF). REST suppresses the nonspecific and premature expression of neuronal genes in non-neuronal and neural progenitor cells, respectively, via recruitment of enzymatic...

Rest Interacts with Cbx Proteins and Regulates Polycomb Repressive Complex 1 Occupancy at 1 Re1 Elements 2 3 Transcription Regulatory Protein Interactions 16 Repressor Element 1 Silencing Transcription Factor / Neuron Restrictive Silencing Factor 17

Polycomb Repressive Complex 1 18 Bimolecular fluorescence complementation analysis of interactions in living cells 19 Chromatin immunoprecipitation analysis of regulatory element binding 20 Embryonic stem cell differentiation into neuronal progenitor cells 21 Integration of epigenetic and DNA sequence-dependent transcription regulation 22 2 23 Polycomb group (PcG) proteins control epigenetic in...